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Fast and High Efficiency HPLC Separations Using Superficially Porous Particles

In our last blog, we noted that chromatographers often wish that their HPLC separations were faster or that their peaks were better resolved.  We discussed how using columns packed with sub-2 µm fully porous particles (FPPs) can help to achieve both of those goals, but that there’s a price to […]

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Fast and High Efficiency HPLC Separations Using Sub-2µm Particles

As chromatographers, whether we’re working in the early stages of column screening or in the latter stages of method development and optimization, we often wish that our separations were:  faster,  more efficient with higher plate counts so we can achieve better peak resolution, or  faster and more efficient.  In this […]

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Getting Started with Chiral Method Development Part Three: Method Development Optimization

In Part 2 of our series on Chiral Method Development, we discussed the features of several different types of chiral stationary phases (CSPs).  We also discussed a general approach to column and mobile phase screening, which can be helpful for identifying candidates to carry on for further method development and […]

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Getting Started with Chiral Method Development Part Two: Finding a CSP

In a previous blog, we discussed the concept of molecular chirality and its importance.  We also noted the ability to separate enantiomers using chiral chromatography.  In this installment, we’ll talk about the first steps in developing an HPLC method that will separate chiral compounds of interest. With any approach to […]

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Supercritical Fluid Chromatography: A Greener, Cheaper, and Faster Alternative in Normal Phase Chromatography

With Earth Day upon us, we are seeing a focus on how companies are trying to do their part to be environmentally friendly. Businesses worldwide are implementing green initiatives, and those initiatives may look quite different depending on the industry. In some sectors, going green means installing solar panels. In […]

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